Adrenomedullin in mammalian embryogenesis

Adrenomedullin in mammalian embryogenesis.

Here are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expression in vascular, neural, and skeletal-forming tissues as well as in the main embryonic internal or...

Energy metabolism during mammalian embryogenesis

would suggest that the enzyme responsible for mediumchain fatty acid activation is not active at this time. The lack of antagonism of salicylate and octanoate against the embryotoxic effects of valproate is also compatible with the mechanisms of teratogenicity and hepatotoxicity being fundamentally different. Although these data rule out one possibility, they provide little direct information o...

Cell mingling during mammalian embryogenesis.

Growth factor superfamilies and mammalian embryogenesis.

With the availability of amino acid and nucleotide sequence information has come the realization that growth factors can be clustered in to superfamilies. Several of these superfamilies contain molecules that were not initially identified because of growth-promoting activities; rather they were discovered through their ability to regulate other processes. Certain members of these superfamilies ...

Expression of Adrenomedullin and Its Receptor during Embryogenesis Suggests Autocrine or Paracrine Modes of Action.

The present study reports the developmental patterns of expression of adrenomedullin (AM) in rat and mouse embryos. AM is a novel multifunctional peptide recently isolated from a human pheochromocytoma, which has been shown to promote growth in a variety of mammalian cell lines. We have applied several techniques to investigate the localization of both the AM peptide and its receptor throughout...